For adults with moderately to severely active ulcerative colitis (UC).

TREMFYA®

DOSING

TREMFYA® is the only IL-23 blocker for UC to offer self-administration from the start

If your healthcare provider decides that you or a caregiver may be able to give your injections at home, you should receive training on the right way to prepare and inject before attempting to inject yourself.

There are two options to get started with TREMFYA®:

Injections under the skin with subcutaneous (SC) injections

OR

Through a vein in the arm with intravenous (IV) infusions

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Hospital icon
INITIAL DOSES

SC INJECTIONS  under the skin

Your first 3 doses may be taken as 2 SC injections every 4 weeks.*

WEEK 0

Icon of an IV with the text '200 mg'
Icon of an IV with the text '200 mg'

400 MG

WEEK 4

Icon of an IV with the text '200 mg'
Icon of an IV with the text '200 mg'

400 MG

WEEK 8

Icon of an IV with the text '200 mg'
Icon of an IV with the text '200 mg'

400 MG

*Each 400 mg dosage will be given as two consecutive injections of 200 mg.

OR

INTRAVENOUS (IV) INFUSION through a vein in the arm

You may be given an IV infusion every 4 weeks at a healthcare facility. It takes at least 1 hour for each dose.

WEEK 0

Icon of an IV with the text '200 mg'
Icon of an IV with the text '200 mg'

200 MG

WEEK 4

Icon of an IV with the text '200 mg'
Icon of an IV with the text '200 mg'

200 MG

WEEK 8

Icon of an IV with the text '200 mg'
Icon of an IV with the text '200 mg'

200 MG

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MAINTENANCE
DOSES

SC INJECTIONS

After finishing your initial doses, you will receive TREMFYA® subcutaneously (under the skin) as:

  • A 200 mg dose every 4 weeks starting at week 12

OR

  • A 100 mg dose every 8 weeks starting at week 16

WEEK 12

Prefilled Syringe of TREMFYA(R) (guselkumab) with the test of '200 mg/2 mL or 100 mg/ML'
AND EVERY 4 WEEKS AFTER
Icon of the TREMFYA® (guselkumab) pen with the text 200 mg

200 MG

OR

WEEK 16

Icon of the TREMFYA® (guselkumab) pen with the text 200 mg
AND EVERY 8 WEEKS AFTER
Prefilled Syringe of TREMFYA(R) (guselkumab) with the test of '200 mg/2 mL or 100 mg/ML'

100 MG

Your healthcare provider will prescribe the right dose for you. Use TREMFYA® exactly as prescribed.

IMPORTANT: Read the detailed Instructions for Use (IFU) that comes with your TREMFYA® medication for information on how to prepare and administer TREMFYA®.

IL=interleukin.

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Administration options for TREMFYA®

Once you have had your first three initial doses, you will take TREMFYA® as a subcutaneous injection.

After your healthcare provider decides how much medicine you’ll be injecting, and how often, you can discuss which injection device may be appropriate for you.

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TREMFYA® Pen (guselkumab) dosing device

TREMFYA® PEN

200 mg/2 mL or 100 mg/mL

Not actual size 200 mg/2 mL TREMFYA® PEN pictured

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Prefilled Syringe TREMFYA® (guselkumab) dosing device

Prefilled Syringe

200 mg/2 mL or 100 mg/mL

Not actual size 200 mg/2 mL prefilled syringe pictured

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The One-Press patient-controlled injector is available as an alternative device option.
Talk to your healthcare provider about which administration option is right for you.

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Turquoise bottom vector banner image

If you’re starting TREMFYA® subcutaneously, you may receive a TREMFYA® Induction Pack for your initial doses.

Explore resources designed to help you understand where and how to inject TREMFYA® with the prefilled pen.

Watch the TREMFYA® PEN demonstration video
Tremfya Pen Dosing